Scientists’ latest discovery will block fentanyl from entering the brain and stop users from getting high

Scientists believe they have created a vaccine that will prevent fentanyl from entering the brain and prevent users from getting high.

According to a study published in the journal Pharmaceutics, the vaccine “generated large levels” of anti-fentanyl antibodies in testing on rats that stuck to the fatally addictive synthetic opioid.

According to lead author Colin Haile of the Drug Discovery Institute at the University of Houston, this prevented the medication from “entering the brain, allowing it to be cleared out of the body via the kidneys.”

“Thus, the individual will not feel the euphoric effects and can ‘get back on the wagon’ to sobriety,” said Haile, predicting it “could have a significant impact on a very serious problem plaguing society for years.”

Only 2 milligrams of fentanyl can be lethal because it is up to 50 times stronger than heroin.

According to the Centers for Disease Control and Prevention, fentanyl overdoses accounted for more than 71,000 American deaths last year, making it by far the most common cause of the 107,622 fatal overdoses overall.

The study revealed that the vaccine “showed efficacy in neutralizing” fentanyl, according to preclinical trials, making it “a potential viable therapy for overuse and overdose in humans.”

Therese Kosten, a professor from the Texas university involved in the study, described it as a potential “game changer.”

According to Kosten, present drugs do not adequately address the treatment problem of fentanyl usage and overdose. The current therapies are ineffective and require many doses, according to Kosten, whereas the vaccine would also serve as a “relapse prevention agent,” according to the study.

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Human clinical trials start soon.

In order to begin human clinical trials, the team intends to begin producing clinical-grade vaccinations in the upcoming months.

The beneficial fentanyl-blocking results came from low, safe doses, according to the researchers, who also said that the vaccination had no adverse side effects in the rats it was tested on.

Due to the fact that the primary components have already been extensively used and studied, they also “anticipate minimal adverse effects in clinical trials.”

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Additionally, because the antibodies were fentanyl-specific, Haile highlighted that a person who had received the vaccination could still receive pain relief from other opioids.

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